Definitions
There are 4 meanings of the phrase
Screw Up.
Screw Up - as a verb
Make a mess of, destroy or ruin
Example: "I botched the dinner and we had to eat out"
Synonyms (Exact Relations)
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Twist into a strained configuration
Example: "Screw up one's face"
Example Sentences
"I don't want to screw up this important meeting."
"Please don't screw up my carefully laid plans."
"He always manages to screw up every task he's given."
"If you keep ignoring the instructions, you're going to screw up the experiment."
"I don't want to screw up our friendship by getting involved romantically."